Games like Genome Guardian
Games like Genome Guardian include Vampire Survivors, Brotato, Megabonk, 20 Minutes Till Dawn, and Hades. We matched them by the tags players give Genome Guardian on Steam (Action Roguelike, Shooter, Roguelite, Gun Customization, and Roguelike): closest matches first, and among equally close ones the better-known games.
Vampire Survivors
Shared: Action Roguelike · Roguelite · Roguelike
Brotato
Shared: Action Roguelike · Roguelike · Roguelite
Megabonk
Shared: Action Roguelike · Roguelite · Roguelike
20 Minutes Till Dawn
Shared: Action Roguelike · Roguelite · Survival
Hades
Shared: Action Roguelike · Roguelite · Roguelike
Risk of Rain 2
Shared: Action Roguelike · Roguelite · Roguelike
Nuclear Throne
Shared: Action Roguelike · Roguelike · Roguelite
Hades II
Shared: Roguelite · Roguelike · Action Roguelike
Halls of Torment
Shared: Action Roguelike · Roguelite · Roguelike
SULFUR
Shared: Action Roguelike · Gun Customization · Roguelite
BALL x PIT
Shared: Roguelite · Action Roguelike · Roguelike
Gunfire Reborn
Shared: Roguelite · Roguelike · Action Roguelike
SYNTHETIK: Legion Rising
Shared: Roguelite · Action Roguelike · Top-Down Shooter
SYNTHETIK 2
Shared: Action Roguelike · Roguelite · Top-Down Shooter
Death Must Die
Shared: Action Roguelike · Roguelite · Roguelike
Blazing Beaks
Shared: Action Roguelike · Roguelite · Roguelike
Yet Another Zombie Survivors
Shared: Action Roguelike · Roguelite · Top-Down Shooter
Nova Drift
Shared: Roguelite · Action Roguelike · Shooter
Enter the Gungeon
Shared: Action Roguelike · Roguelike · Bullet Hell
Roboquest
Shared: Action Roguelike · Roguelite · Shooter
Army of Ruin
Shared: Action Roguelike · Roguelite · Shooter
Rocket Rats
Shared: Action Roguelike · Roguelite · Shooter
The Last Stand: Aftermath
Shared: Roguelite · Shooter · Action Roguelike
Pathogenic
Shared: Roguelike · Action Roguelike · Top-Down Shooter