Games like Genome Guardian 2
Games like Genome Guardian 2 include Megabonk, Brotato, Deep Rock Galactic: Survivor, Vampire Survivors, and NIMRODS. We matched them by the tags players give Genome Guardian 2 on Steam (Gun Customization, Bullet Heaven, Roguelite, Action, and Casual): closest matches first, and among equally close ones the better-known games.

Megabonk
Shared: Bullet Heaven · Roguelite · Action Roguelike

Brotato
Shared: Bullet Heaven · Roguelike · Roguelite

Deep Rock Galactic: Survivor
Shared: Bullet Heaven · Roguelite · Top-Down Shooter

Vampire Survivors
Shared: Roguelite · Action Roguelike · Casual

NIMRODS
Shared: Gun Customization · Bullet Heaven · Roguelite

Soulstone Survivors
Shared: Bullet Heaven · Roguelite · Action Roguelike

Death Must Die
Shared: Roguelite · Bullet Heaven · Action

Time Wasters
Shared: Bullet Heaven · Roguelite · Twin Stick Shooter

BALL x PIT
Shared: Roguelite · Action · Top-Down Shooter

Yet Another Zombie Survivors
Shared: Bullet Heaven · Roguelite · Top-Down Shooter

20 Minutes Till Dawn
Shared: Roguelite · Action Roguelike · Top-Down Shooter

SYNTHETIK: Legion Rising
Shared: Roguelite · Action · Top-Down Shooter

The Spell Brigade
Shared: Bullet Heaven · Roguelite · Action

Arms of God
Shared: Bullet Heaven · Roguelite · Top-Down Shooter

Halls of Torment
Shared: Roguelite · Action · Action Roguelike

SYNTHETIK 2
Shared: Roguelite · Top-Down Shooter · Twin Stick Shooter

Hades
Shared: Roguelite · Action · Action Roguelike

Nordic Ashes: Survivors of Ragnarok
Shared: Bullet Heaven · Roguelite · Action Roguelike

Nuclear Throne
Shared: Action · Roguelite · Action Roguelike

Nova Drift
Shared: Roguelite · Bullet Heaven · Action Roguelike

Rogue: Genesia
Shared: Bullet Heaven · Roguelite · Twin Stick Shooter

Tower of Babel: Survivors of Chaos
Shared: Bullet Heaven · Roguelite · Action

Atomicrops
Shared: Action · Roguelite · Bullet Heaven

Blazing Beaks
Shared: Roguelite · Action · Top-Down Shooter