Games like Genetic Disaster
Games like Genetic Disaster include Risk of Rain 2, Hades, Risk of Rain (2013), The Binding of Isaac: Rebirth, and Ravenswatch. We matched them by the tags players give Genetic Disaster on Steam (Indie, Action Roguelike, Action, and Roguelike): closest matches first, and among equally close ones the better-known games.

Risk of Rain 2
Shared: Action Roguelike · Co-op · Roguelike

Hades
Shared: Action Roguelike · Indie · Action

Risk of Rain (2013)
Shared: Action Roguelike · Indie · Roguelike

The Binding of Isaac: Rebirth
Shared: Action Roguelike · Indie · Roguelike

Ravenswatch
Shared: Action Roguelike · Co-op · Roguelike

Skul: The Hero Slayer
Shared: Indie · Action Roguelike · Action

Gunfire Reborn
Shared: Roguelike · Co-op · Indie

Enter the Gungeon
Shared: Action Roguelike · Roguelike · Indie

The Binding of Isaac
Shared: Action Roguelike · Indie · Roguelike

Megabonk
Shared: Action Roguelike · Indie · Roguelike

Nuclear Throne
Shared: Action Roguelike · Indie · Roguelike

Hades II
Shared: Action · Roguelike · Action Roguelike

Streets of Rogue
Shared: Action Roguelike · Indie · Action

Vampire Survivors
Shared: Action Roguelike · Indie · Roguelike

Sephiria
Shared: Action Roguelike · Co-op · Roguelike

SYNTHETIK: Legion Rising
Shared: Indie · Action · Action Roguelike

Wizard of Legend
Shared: Action Roguelike · Roguelike · Action

Rogue Legacy
Shared: Indie · Action Roguelike · Roguelike

Hero Siege
Shared: Action Roguelike · Co-op · Indie

SWORN
Shared: Indie · Action Roguelike · Co-op

Rampage Knights
Shared: Action Roguelike · Co-op · Action

Spelunky
Shared: Action Roguelike · Indie · Roguelike

Rabbit and Steel
Shared: Action Roguelike · Co-op · Roguelike

Crab Champions
Shared: Action Roguelike · Roguelike · Co-op