Games like Gems Defenders
Games like Gems Defenders include Kingdom Rush - Tower Defense, CrossCode, The Escapists, UFO 50, and Eastward. We matched them by the tags players give Gems Defenders on Steam (Match 3, Tower Defense, Pixel Graphics, Action, and 2D): closest matches first, and among equally close ones the better-known games.

Kingdom Rush - Tower Defense
Shared: Tower Defense · 2D · Action

CrossCode
Shared: Pixel Graphics · 2D · Action RPG

The Escapists
Shared: Pixel Graphics · 2D · Action

UFO 50
Shared: Pixel Graphics · Action · 2D

Eastward
Shared: Pixel Graphics · Adventure · Action

Kingdom Rush Frontiers - Tower Defense
Shared: Tower Defense · 2D · Strategy

Kingdom Rush Vengeance - Tower Defense
Shared: Tower Defense · 2D · Medieval

Kingdom Rush Origins - Tower Defense
Shared: Tower Defense · 2D · Medieval

Hero Siege
Shared: Pixel Graphics · Action RPG · Action

Hyper Light Drifter
Shared: Pixel Graphics · Adventure · Action

Terraria
Shared: Pixel Graphics · 2D · Adventure

Kingdom Rush 6: Genesis TD
Shared: Tower Defense · Action · 2D

Kingdom Rush 5: Alliance TD
Shared: Tower Defense · 2D · Strategy

Oceans Heart
Shared: Pixel Graphics · Action · 2D

SANABI
Shared: Pixel Graphics · Action · Adventure

Iconoclasts
Shared: Pixel Graphics · Action · Adventure

Plants vs. Zombies GOTY Edition
Shared: Tower Defense · 2D · Strategy

10,000,000
Shared: Match 3 · Pixel Graphics · Puzzle

Zuma Deluxe
Shared: Match 3 · 2D · Puzzle

Broforce
Shared: Pixel Graphics · Action · 2D

Dungeon Munchies
Shared: Pixel Graphics · Action · Adventure

Shovel Knight: Treasure Trove
Shared: Pixel Graphics · 2D · Action

Dragon's Dogma 2
Shared: Action · Adventure · Action RPG

There Is No Game: Wrong Dimension
Shared: Pixel Graphics · Adventure · Puzzle