Games like Galactic Siege
Games like Galactic Siege include The Alters, Oxygen Not Included, RimWorld, Bloons TD 6, and Orcs Must Die! 3. We matched them by the tags players give Galactic Siege on Steam (Strategy, Tower Defense, PvE, 3D, and Magic): closest matches first, and among equally close ones the better-known games.

The Alters
Shared: Strategy · Management · Survival

Oxygen Not Included
Shared: Survival · Management · Strategy

RimWorld
Shared: Strategy · Management · Survival

Bloons TD 6
Shared: Strategy · Tower Defense · 3D

Orcs Must Die! 3
Shared: Tower Defense · Strategy · PvE

Dyson Sphere Program
Shared: Space · Sci-fi · Strategy

Legion TD 2 - Multiplayer Tower Defense
Shared: Tower Defense · Strategy · PvE

Stellaris
Shared: Strategy · Space · Sci-fi

Sanctum 2
Shared: Tower Defense · Strategy · Sci-fi

FTL: Faster Than Light
Shared: Strategy · Space · Sci-fi

Age of Darkness: Final Stand
Shared: Tower Defense · Strategy · PvE

Defense Grid: The Awakening
Shared: Strategy · Tower Defense · Sci-fi

Space Haven
Shared: Strategy · Management · Survival

Thronefall
Shared: Strategy · Tower Defense · 3D

Outpost: Infinity Siege
Shared: Tower Defense · 3D · Strategy

Taur
Shared: Strategy · Tower Defense · Sci-fi

They Are Billions
Shared: Strategy · Tower Defense · Survival

Creeper World 3: Arc Eternal
Shared: Strategy · Tower Defense · Sci-fi

Space Run
Shared: Strategy · Tower Defense · Space

Warhammer 40,000: Space Marine 2
Shared: PvE · Action · Sci-fi

Dungeon Defenders
Shared: Tower Defense · Strategy · Survival

Mindustry
Shared: Tower Defense · Strategy · Resource Management

Spacebase DF-9
Shared: Strategy · Space · Sci-fi

Planetbase
Shared: Strategy · Space · Survival