Games like Farm Defence
Games like Farm Defence include Rusty's Retirement, Stardew Valley, Papers, Please, Farming Simulator 19, and Potion Craft: Alchemist Simulator. We matched them by the tags players give Farm Defence on Steam (Simulation, Farming Sim, Idler, 2D, and Retro): closest matches first, and among equally close ones the better-known games.

Rusty's Retirement
Shared: Farming Sim · Idler · Simulation

Stardew Valley
Shared: Farming Sim · Simulation · Singleplayer

Papers, Please
Shared: Simulation · Singleplayer · Retro

Farming Simulator 19
Shared: Simulation · Farming Sim · Singleplayer

Potion Craft: Alchemist Simulator
Shared: Simulation · Singleplayer · 2D

The Farmer Was Replaced
Shared: Idler · Farming Sim · Automation

Nodebuster
Shared: Simulation · Idler · 2D

Your Big, Cute Monster Farm
Shared: Simulation · Farming Sim · Idler

Maltese's Fluffy Onsen
Shared: Simulation · Idler · 2D

Melvor Idle
Shared: Idler · Singleplayer · 2D

鬼谷八荒 Tale of Immortal
Shared: Simulation · Singleplayer · 2D

Fortune Mill
Shared: Idler · Simulation · Automation

Farming Simulator 17
Shared: Simulation · Farming Sim · Singleplayer

Tiny Pasture
Shared: Idler · Farming Sim · Simulation

Plants vs. Zombies GOTY Edition
Shared: Tower Defense · Singleplayer · 2D

Ranch Simulator: Build, Hunt, Farm
Shared: Simulation · Farming Sim · Singleplayer

Plantera
Shared: Idler · Farming Sim · Automation

People Playground
Shared: 2D · Simulation · Singleplayer

Farming Simulator 15
Shared: Farming Sim · Simulation · Singleplayer

Game Dev Tycoon
Shared: Simulation · Singleplayer · 2D

Farming Simulator 22
Shared: Simulation · Farming Sim · Singleplayer

Idle Deepcore
Shared: Idler · Simulation · Automation

Coral Island
Shared: Farming Sim · Simulation · Singleplayer

All Hail the Orb
Shared: Simulation · Idler · 2D