Games like Escape: The Research Center
Games like Escape: The Research Center include The Room, Blue Prince, Poppy Playtime, Firewatch, and Return of the Obra Dinn. We matched them by the tags players give Escape: The Research Center on Steam (Adventure, Puzzle, Singleplayer, Science, and Mystery): closest matches first, and among equally close ones the better-known games.

The Room
Shared: Puzzle · Mystery · Adventure

Blue Prince
Shared: Puzzle · Mystery · Singleplayer

Poppy Playtime
Shared: Singleplayer · Puzzle · First-Person

Firewatch
Shared: Adventure · Atmospheric · Mystery

Return of the Obra Dinn
Shared: Puzzle · Mystery · Singleplayer

Outer Wilds
Shared: Adventure · Mystery · Puzzle

The Room Three
Shared: Puzzle · Adventure · Mystery

Riven
Shared: Adventure · Puzzle · Singleplayer

The Room Two
Shared: Puzzle · Mystery · Adventure

What Remains of Edith Finch
Shared: Atmospheric · Adventure · Mystery

The Room 4: Old Sins
Shared: Puzzle · Adventure · Mystery

Chants of Sennaar
Shared: Adventure · Puzzle · Singleplayer

Stray
Shared: Adventure · Singleplayer · Atmospheric

Quern - Undying Thoughts
Shared: Adventure · Puzzle · Mystery

The Talos Principle
Shared: Puzzle · Singleplayer · First-Person

The Witness
Shared: Puzzle · Singleplayer · First-Person

Call of the Sea
Shared: Adventure · Puzzle · First-Person

Murders on the Yangtze River
Shared: Puzzle · Adventure · Mystery

Portal 2
Shared: Singleplayer · Puzzle · First-Person

A Story About My Uncle
Shared: Adventure · Singleplayer · First-Person

Sherlock Holmes: The Devil's Daughter
Shared: Adventure · Puzzle · Mystery

The Last Campfire
Shared: Adventure · Puzzle · Singleplayer

Little Nightmares
Shared: Adventure · Singleplayer · Atmospheric

The Room VR: A Dark Matter
Shared: Adventure · Puzzle · Mystery