Games like Enter the Depths
Games like Enter the Depths include The Binding of Isaac: Rebirth, Balatro, Skul: The Hero Slayer, Vampire Crawlers: The Turbo Wildcard from Vampire Survivors, and Loop Hero. We matched them by the tags players give Enter the Depths on Steam (Roguelike, Action, Deckbuilding, Singleplayer, and Minimalist): closest matches first, and among equally close ones the better-known games.

The Binding of Isaac: Rebirth
Shared: Roguelike · Indie · Singleplayer

Balatro
Shared: Roguelike · Deckbuilding · Singleplayer

Skul: The Hero Slayer
Shared: Action · Roguelike · Indie

Vampire Crawlers: The Turbo Wildcard from Vampire Survivors
Shared: Roguelike · Deckbuilding · Action

Loop Hero
Shared: Roguelike · Deckbuilding · Pixel Graphics

Vampire Survivors
Shared: Roguelike · Singleplayer · Pixel Graphics

Slay the Spire 2
Shared: Roguelike · Deckbuilding · Strategy

Slay the Spire
Shared: Roguelike · Deckbuilding · Singleplayer

The Binding of Isaac
Shared: Roguelike · Action · Indie

Rogue Legacy
Shared: Roguelike · Action · Singleplayer

Hades
Shared: Action · Roguelike · Singleplayer

Dungreed
Shared: Roguelike · Action · Pixel Graphics

Enter the Gungeon
Shared: Roguelike · Pixel Graphics · Indie

Dome Keeper
Shared: Roguelike · Singleplayer · Action

Nubby's Number Factory
Shared: Roguelike · Singleplayer · Strategy

Dead Cells
Shared: Roguelike · 2D · Pixel Graphics

Noita
Shared: Roguelike · Pixel Graphics · Indie

Megabonk
Shared: Roguelike · Action · Indie

Risk of Rain (2013)
Shared: Roguelike · Action · Indie

Hand of Fate
Shared: Roguelike · Deckbuilding · Action

FTL: Faster Than Light
Shared: Roguelike · Singleplayer · Strategy

Peglin
Shared: Roguelike · Deckbuilding · Strategy

The Escapists
Shared: Singleplayer · Strategy · Action

Hades II
Shared: Roguelike · Action · Singleplayer