Games like Enter the Chronosphere
Games like Enter the Chronosphere include FTL: Faster Than Light, The Binding of Isaac, The Binding of Isaac: Rebirth, Heat Signature, and Invisible, Inc.. We matched them by the tags players give Enter the Chronosphere on Steam (Space, Difficult, Sci-fi, Action Roguelike, and Strategy): closest matches first, and among equally close ones the better-known games.

FTL: Faster Than Light
Shared: Space · Sci-fi · Roguelike

The Binding of Isaac
Shared: Action Roguelike · Difficult · Roguelike

The Binding of Isaac: Rebirth
Shared: Action Roguelike · Difficult · Roguelike

Heat Signature
Shared: Space · Roguelike · Sci-fi

Invisible, Inc.
Shared: Difficult · Strategy · Turn-Based Tactics

Enter the Gungeon
Shared: Action Roguelike · Difficult · Roguelike

BattleTech
Shared: Strategy · Sci-fi · Turn-Based

Nuclear Throne
Shared: Action Roguelike · Difficult · Roguelike

XCOM: Enemy Unknown
Shared: Sci-fi · Strategy · Difficult

Warhammer 40,000: Mechanicus
Shared: Strategy · Sci-fi · Turn-Based Tactics

Darkest Dungeon®
Shared: Difficult · Roguelike · Turn-Based

Cosmoteer: Starship Architect & Commander
Shared: Sci-fi · Space · Strategy

EVERSPACE™
Shared: Space · Action Roguelike · Sci-fi

Spelunky
Shared: Action Roguelike · Difficult · Roguelike

Skul: The Hero Slayer
Shared: Action Roguelike · Roguelike · Difficult

Slay the Spire 2
Shared: Roguelike · Strategy · Difficult

Stoneshard
Shared: Roguelike · Strategy · Turn-Based

Into the Breach
Shared: Strategy · Roguelike · Turn-Based Tactics

Space Pirates and Zombies
Shared: Space · Sci-fi · Strategy

ENDLESS Space™ 2
Shared: Space · Sci-fi · Strategy

Slay the Spire
Shared: Roguelike · Strategy · Turn-Based

Noita
Shared: Difficult · Roguelike · Action Roguelike

XCOM®: Chimera Squad
Shared: Strategy · Sci-fi · Turn-Based Tactics

Void War
Shared: Space · Difficult · Strategy