Games like Empires in Ruins
Games like Empires in Ruins include Manor Lords, Stronghold: Definitive Edition, Workers & Resources: Soviet Republic, Crusader Kings III, and Against the Storm. We matched them by the tags players give Empires in Ruins on Steam (Wargame, Sandbox, Tower Defense, City Builder, and RTS): closest matches first, and among equally close ones the better-known games.

Manor Lords
Shared: City Builder · Sandbox · Grand Strategy

Stronghold: Definitive Edition
Shared: City Builder · Sandbox · RTS

Workers & Resources: Soviet Republic
Shared: City Builder · Grand Strategy · Base Building

Crusader Kings III
Shared: Grand Strategy · Sandbox · RPG

Against the Storm
Shared: City Builder · Base Building · Grand Strategy

Kingdoms and Castles
Shared: City Builder · Sandbox · Base Building

Empires of the Undergrowth
Shared: City Builder · Base Building · Sandbox

Medieval Kingdom Wars
Shared: RTS · Grand Strategy · City Builder

Stronghold HD (2012)
Shared: City Builder · Sandbox · Tower Defense

Foundation
Shared: City Builder · Sandbox · Simulation

Stronghold Crusader: Definitive Edition
Shared: City Builder · Sandbox · Tower Defense

Lessaria: Fantasy Kingdom Sim
Shared: City Builder · RTS · Tower Defense

RimWorld
Shared: Sandbox · Base Building · Strategy

Total War: WARHAMMER
Shared: RPG · RTS · Grand Strategy

They Are Billions
Shared: Base Building · Tower Defense · RTS

The Riftbreaker
Shared: Tower Defense · Base Building · Sandbox

Prison Architect
Shared: Sandbox · City Builder · Base Building

Norland
Shared: City Builder · Base Building · Sandbox

Songs of Syx
Shared: City Builder · Sandbox · Grand Strategy

Ultimate Epic Battle Simulator 2
Shared: Sandbox · Wargame · RTS

Cities: Skylines
Shared: City Builder · Sandbox · Simulation

Infection Free Zone
Shared: City Builder · Base Building · RTS

Kingdom Two Crowns
Shared: Tower Defense · City Builder · Base Building

Stronghold Crusader HD (2012)
Shared: City Builder · Sandbox · Base Building