Games like Eclipse Protocol 2130
Games like Eclipse Protocol 2130 include Vampire Survivors, Windowkill, Skul: The Hero Slayer, Megabonk, and Rogue Legacy. We matched them by the tags players give Eclipse Protocol 2130 on Steam (Action, Arcade, Action Roguelike, Twin Stick Shooter, and 2D): closest matches first, and among equally close ones the better-known games.

Vampire Survivors
Shared: Action Roguelike · 2D · Indie

Windowkill
Shared: Action · Action Roguelike · Arcade

Skul: The Hero Slayer
Shared: Action · Action Roguelike · Indie

Megabonk
Shared: Action Roguelike · Action · Indie

Rogue Legacy
Shared: Action · Action Roguelike · Indie

Cyberhunt
Shared: Action · Indie · Arcade

Hades
Shared: Action Roguelike · Action · Indie

Timberman
Shared: Action · Indie · Arcade

A Dance of Fire and Ice
Shared: Arcade · Singleplayer · 2D

BALL x PIT
Shared: Action · Arcade · Action Roguelike

The Binding of Isaac: Rebirth
Shared: Action Roguelike · Indie · Singleplayer

Rogue Legacy 2
Shared: Arcade · Action · Indie

BlazBlue Entropy Effect
Shared: Action · Action Roguelike · 2D

Downwell
Shared: Action Roguelike · Arcade · Action

Boneraiser Minions
Shared: Action Roguelike · 2D · Arcade

Enter the Gungeon
Shared: Action Roguelike · Indie · Twin Stick Shooter

Spelunky
Shared: Action Roguelike · 2D · Indie

One Finger Death Punch
Shared: Action · Indie · Singleplayer

The Binding of Isaac
Shared: Action Roguelike · Action · Indie

DJMAX RESPECT V
Shared: Action · Casual · Singleplayer

Streets of Rage 4
Shared: Action · Arcade · 2D

Halls of Torment
Shared: Action Roguelike · Action · Arcade

Geometry Wars: Retro Evolved
Shared: Arcade · Twin Stick Shooter · Singleplayer

Dungreed
Shared: Action Roguelike · Action · 2D