Games like Drug Empire
Games like Drug Empire include PowerWash Simulator, Potion Craft: Alchemist Simulator, PC Building Simulator, Supermarket Simulator, and House Flipper. We matched them by the tags players give Drug Empire on Steam (Simulation, Casual, Crime, Sandbox, and Immersive Sim): closest matches first, and among equally close ones the better-known games.

PowerWash Simulator
Shared: Casual · Simulation · Sandbox

Potion Craft: Alchemist Simulator
Shared: Simulation · Crafting · Casual

PC Building Simulator
Shared: Simulation · Immersive Sim · Sandbox

Supermarket Simulator
Shared: Simulation · Immersive Sim · Trading

House Flipper
Shared: Simulation · Casual · Sandbox

Big Ambitions
Shared: Simulation · Sandbox · Capitalism

Drug Dealer Simulator
Shared: Simulation · Crime · Crafting

King of Retail
Shared: Simulation · Casual · Immersive Sim

Retro Rewind - Video Store Simulator
Shared: Simulation · Casual · Immersive Sim

Stardew Valley
Shared: Simulation · Sandbox · Crafting

PowerWash Simulator 2
Shared: Casual · Simulation · Sandbox

DrainSim
Shared: Simulation · Casual · Sandbox

Totally Accurate Battle Simulator
Shared: Simulation · Sandbox · Colorful

Waterpark Simulator
Shared: Simulation · Sandbox · Immersive Sim

TCG Card Shop Simulator
Shared: Simulation · Capitalism · Singleplayer

My Dream Setup
Shared: Simulation · Casual · Sandbox

Recycling Center Simulator
Shared: Simulation · Immersive Sim · Time Management

Mall Simulator
Shared: Simulation · Immersive Sim · Capitalism

Schedule I
Shared: Simulation · Crime · Crafting

Planet Coaster
Shared: Simulation · Sandbox · Relaxing

Kenshi
Shared: Sandbox · Simulation · Immersive Sim

112 Operator
Shared: Simulation · Casual · Time Management

Hozy
Shared: Casual · Sandbox · Simulation

Garry's Mod
Shared: Sandbox · Casual · Simulation