Games like Dr. Spacezoo
Games like Dr. Spacezoo include Broforce, Enter the Gungeon, Cuphead, Hotline Miami, and Skul: The Hero Slayer. We matched them by the tags players give Dr. Spacezoo on Steam (Action, Indie, Early Access, Twin Stick Shooter, and 4 Player Local): closest matches first, and among equally close ones the better-known games.

Broforce
Shared: Action · Indie · Local Co-Op

Enter the Gungeon
Shared: Indie · Difficult · Local Co-Op

Cuphead
Shared: Difficult · Local Co-Op · Indie

Hotline Miami
Shared: Action · Indie · Pixel Graphics

Skul: The Hero Slayer
Shared: Action · Indie · Pixel Graphics

UFO 50
Shared: Indie · Action · Retro

Duck Game
Shared: Action · Indie · 4 Player Local

Shovel Knight: Treasure Trove
Shared: Indie · Action · Retro

The Binding of Isaac: Rebirth
Shared: Indie · Difficult · Pixel Graphics

Risk of Rain (2013)
Shared: Indie · Action · Pixel Graphics

Hotline Miami 2: Wrong Number
Shared: Action · Indie · Pixel Graphics

Cyberhunt
Shared: Action · Indie · Twin Stick Shooter

Blazing Chrome
Shared: Action · Indie · Retro

SANABI
Shared: Action · Indie · Pixel Graphics

Noita
Shared: Indie · Difficult · Pixel Graphics

Nuclear Throne
Shared: Indie · Action · Difficult

Katana ZERO
Shared: Action · Indie · Pixel Graphics

TowerFall Ascension
Shared: Indie · Action · Local Co-Op

Vampire Survivors
Shared: Indie · Pixel Graphics · Action

Ultratron
Shared: Action · Indie · Twin Stick Shooter

Jump King
Shared: Indie · Difficult · Action

Super Meat Boy
Shared: Indie · Difficult · 2D

Huntdown
Shared: Action · Local Co-Op · Pixel Graphics

Mother Russia Bleeds
Shared: Action · Indie · Local Co-Op