Games like DNA Farm
Games like DNA Farm include Hollow Knight, MIO: Memories in Orbit, Hollow Knight: Silksong, Constance, and Well Dweller. We matched them by the tags players give DNA Farm on Steam (Choices Matter, Action-Adventure, Hand-drawn, Metroidvania, and Time Management): closest matches first, and among equally close ones the better-known games.

Hollow Knight
Shared: Metroidvania · Hand-drawn · Indie

MIO: Memories in Orbit
Shared: Metroidvania · Action-Adventure · Hand-drawn

Hollow Knight: Silksong
Shared: Metroidvania · Indie · Adventure

Constance
Shared: Metroidvania · Action-Adventure · Hand-drawn

Well Dweller
Shared: Action-Adventure · Metroidvania · Hand-drawn

Nine Sols
Shared: Metroidvania · Hand-drawn · Indie

Ori and the Will of the Wisps
Shared: Metroidvania · Action-Adventure · Adventure

Prince of Persia The Lost Crown
Shared: Metroidvania · Action-Adventure · Adventure

HAAK
Shared: Metroidvania · Action-Adventure · Underground

Crypt Custodian
Shared: Metroidvania · Action-Adventure · Adventure

F.I.S.T.: Forged In Shadow Torch
Shared: Metroidvania · Action-Adventure · Adventure

8Doors: Arum's Afterlife Adventure
Shared: Metroidvania · Action-Adventure · Hand-drawn

Marvel's Guardians of the Galaxy
Shared: Action-Adventure · Choices Matter · Adventure

Souldiers
Shared: Metroidvania · Action-Adventure · Adventure

Demon Slayer -Kimetsu no Yaiba- The Hinokami Chronicles
Shared: Action-Adventure · Demons · Adventure

Wonder Boy: The Dragon's Trap
Shared: Metroidvania · Hand-drawn · Adventure

Kingdom Rush Vengeance - Tower Defense
Shared: Choices Matter · Action-Adventure · Demons

The Dark Pictures Anthology: House of Ashes
Shared: Choices Matter · Action-Adventure · Demons

Bloody Hell
Shared: Metroidvania · Demons · Indie

The Darkest Tales — Into the Nightmare
Shared: Action-Adventure · Metroidvania · Adventure

ITORAH
Shared: Metroidvania · Hand-drawn · Action-Adventure

Silver Pines
Shared: Metroidvania · Action-Adventure · Inventory Management

Blasphemous 2
Shared: Metroidvania · Combat · Adventure

Slay the Princess — The Pristine Cut
Shared: Choices Matter · Hand-drawn · Indie