Games like DNA: Episode 5
Games like DNA: Episode 5 include ICEY, Dungeon Fighter Online, Absolum, ONE PIECE: PIRATE WARRIORS 4, and The Vagrant. We matched them by the tags players give DNA: Episode 5 on Steam (Action, RPG, 2D Fighter, Arcade, and Beat 'em up): closest matches first, and among equally close ones the better-known games.

ICEY
Shared: Action · Hack and Slash · Anime

Dungeon Fighter Online
Shared: RPG · 2D Fighter · Beat 'em up

Absolum
Shared: Beat 'em up · Action · RPG

ONE PIECE: PIRATE WARRIORS 4
Shared: Beat 'em up · Action · Hack and Slash

The Vagrant
Shared: Action · RPG · Side Scroller

NieR:Automata™
Shared: RPG · Action · Hack and Slash

Granblue Fantasy: Versus
Shared: Action · 2D Fighter · RPG

Dust: An Elysian Tail
Shared: Action · RPG · Beat 'em up

DRAGON BALL Z: KAKAROT
Shared: Action · RPG · Anime

One Finger Death Punch
Shared: Action · 2D Fighter · Beat 'em up

Eastern Exorcist
Shared: Action · RPG · Side Scroller

Crazy Flasher Series 2021
Shared: Action · RPG · 2D Fighter

Streets of Rage 4
Shared: Action · Beat 'em up · Arcade

GUILTY GEAR -STRIVE-
Shared: 2D Fighter · Arcade · Action

Path of Kung Fu
Shared: RPG · 2D Fighter · Action

Black Myth: Wukong
Shared: Action · RPG · Hack and Slash

DRAGON BALL FighterZ
Shared: Action · 2D Fighter · Anime

God of War
Shared: Action · RPG · Hack and Slash

Sacred 3
Shared: Action · RPG · Arcade

Hades II
Shared: Action · RPG · Hack and Slash

Bladed fury
Shared: Action · RPG · Hack and Slash

Hades
Shared: Action · Hack and Slash · RPG

Rogue Legacy 2
Shared: Action · Arcade · RPG

Dead as Disco
Shared: Beat 'em up · Action · Hack and Slash