Games like DNA: Episode 4
Games like DNA: Episode 4 include ICEY, The Vagrant, Streets of Rage 4, Eastern Exorcist, and Dust: An Elysian Tail. We matched them by the tags players give DNA: Episode 4 on Steam (Action, RPG, 2D Fighter, Arcade, and Beat 'em up): closest matches first, and among equally close ones the better-known games.

ICEY
Shared: Action · Hack and Slash · RPG

The Vagrant
Shared: Action · RPG · 2D

Streets of Rage 4
Shared: Action · Beat 'em up · Arcade

Eastern Exorcist
Shared: Action · RPG · Side Scroller

Dust: An Elysian Tail
Shared: Action · RPG · 2D

One Finger Death Punch
Shared: Action · 2D Fighter · Beat 'em up

Dungeon Fighter Online
Shared: RPG · 2D Fighter · Beat 'em up

Crazy Flasher Series 2021
Shared: Action · RPG · 2D Fighter

Absolum
Shared: Beat 'em up · Action · RPG

GUILTY GEAR -STRIVE-
Shared: 2D Fighter · Arcade · Action

ONE PIECE: PIRATE WARRIORS 4
Shared: Beat 'em up · Action · Hack and Slash

Bladed fury
Shared: Action · RPG · Hack and Slash

Rogue Legacy 2
Shared: Action · Arcade · RPG

Granblue Fantasy: Versus
Shared: Action · 2D Fighter · RPG

NieR:Automata™
Shared: RPG · Action · Hack and Slash

Anomaly Agent
Shared: 2D Platformer · 2D Fighter · Side Scroller

Your Only Move Is HUSTLE
Shared: Action · 2D Fighter · 2D

Path of Kung Fu
Shared: RPG · 2D Fighter · Action

Nickelodeon All-Star Brawl
Shared: 2D Fighter · Action · Beat 'em up

DRAGON BALL Z: KAKAROT
Shared: Action · RPG · Anime

Kung Fury: Street Rage - Ultimate Edition
Shared: Action · Arcade · Beat 'em up

SHINOBI: Art of Vengeance
Shared: Action · 2D Platformer · Hack and Slash

Teenage Mutant Ninja Turtles: Shredder's Revenge
Shared: Beat 'em up · Arcade · Side Scroller

Stick It to the Stickman
Shared: Action · Beat 'em up · 2D Fighter