Games like DNA: Episode 1
Games like DNA: Episode 1 include ICEY, The Vagrant, Dust: An Elysian Tail, One Finger Death Punch, and Streets of Rage 4. We matched them by the tags players give DNA: Episode 1 on Steam (Action, 2D Fighter, Indie, Anime, and Beat 'em up): closest matches first, and among equally close ones the better-known games.

ICEY
Shared: Action · Anime · Indie

The Vagrant
Shared: Action · RPG · 2D

Dust: An Elysian Tail
Shared: Action · Indie · RPG

One Finger Death Punch
Shared: Action · 2D Fighter · Indie

Streets of Rage 4
Shared: Action · Indie · Beat 'em up

Dungeon Munchies
Shared: Action · Indie · Anime

Your Only Move Is HUSTLE
Shared: 2D Fighter · Action · 2D

Bladed fury
Shared: Action · Indie · RPG

DRAGON BALL Z: KAKAROT
Shared: Action · Anime · RPG

Crazy Flasher Series 2021
Shared: Action · 2D Fighter · RPG

Dungeon Fighter Online
Shared: Anime · 2D Fighter · RPG

Eastern Exorcist
Shared: Action · RPG · 2D

Charlie Murder
Shared: Action · Indie · Beat 'em up

Indivisible
Shared: Action · Indie · RPG

Bloodstained: Ritual of the Night
Shared: Action · RPG · Anime

Skullgirls 2nd Encore
Shared: 2D Fighter · Indie · Anime

Absolum
Shared: Beat 'em up · Action · Hand-drawn

Stick It to the Stickman
Shared: Action · 2D Fighter · Beat 'em up

Pyre
Shared: Indie · Action · RPG

Metal Unit
Shared: Action · Indie · RPG

One Finger Death Punch 2
Shared: Action · Indie · Beat 'em up

GUILTY GEAR -STRIVE-
Shared: 2D Fighter · Anime · Action

BlazBlue Entropy Effect
Shared: Action · 2D · Anime

Skul: The Hero Slayer
Shared: Action · Indie · 2D