Games like Distant Worlds: Universe
Games like Distant Worlds: Universe include Stellaris, STAR WARS™ Empire at War - Gold Pack, FTL: Faster Than Light, Europa Universalis IV, and ENDLESS Space™ 2. We matched them by the tags players give Distant Worlds: Universe on Steam (Strategy, 4X, Space, Sci-fi, and Simulation): closest matches first, and among equally close ones the better-known games.

Stellaris
Shared: Strategy · Space · 4X

STAR WARS™ Empire at War - Gold Pack
Shared: Strategy · Space · Sci-fi

FTL: Faster Than Light
Shared: Strategy · Space · Sci-fi

Europa Universalis IV
Shared: Strategy · 4X · Grand Strategy

ENDLESS Space™ 2
Shared: Strategy · Space · 4X

X4: Foundations
Shared: Space · Simulation · 4X

Distant Worlds 2
Shared: Strategy · 4X · Simulation

Sins of a Solar Empire II
Shared: Strategy · Space · 4X

Galactic Civilizations IV
Shared: Space · 4X · Strategy

Sins of a Solar Empire®: Rebellion
Shared: Strategy · Space · Simulation

RimWorld
Shared: Strategy · Singleplayer · Simulation

Sid Meier’s Civilization® VI
Shared: Strategy · 4X · Grand Strategy

Dune: Spice Wars
Shared: Strategy · Sci-fi · 4X

Sid Meier's Civilization®: Beyond Earth™
Shared: Strategy · Space · Sci-fi

Master of Orion
Shared: Strategy · 4X · Space

Supreme Commander: Forged Alliance
Shared: Strategy · Sci-fi · RTS

Crusader Kings III
Shared: Strategy · Simulation · Grand Strategy

Crusader Kings II
Shared: Strategy · Grand Strategy · Simulation

Kerbal Space Program
Shared: Space · Simulation · Sandbox

Anno 2205™
Shared: Strategy · Simulation · 4X

Hearts of Iron IV
Shared: Strategy · Grand Strategy · Simulation

NEBULOUS: Fleet Command
Shared: Strategy · Simulation · Grand Strategy

ENDLESS Space™ - Definitive Edition
Shared: Strategy · 4X · Space

Terra Invicta
Shared: Strategy · 4X · Simulation