Games like Desktop Monsters
Games like Desktop Monsters include Plants vs. Zombies GOTY Edition, Game Dev Tycoon, Bloons TD 6, Oxygen Not Included, and Kingdom Rush - Tower Defense. We matched them by the tags players give Desktop Monsters on Steam (Casual, Strategy, Indie, Tower Defense, and 2D Platformer): closest matches first, and among equally close ones the better-known games.

Plants vs. Zombies GOTY Edition
Shared: Strategy · Tower Defense · Casual

Game Dev Tycoon
Shared: Indie · Strategy · Casual

Bloons TD 6
Shared: Strategy · Tower Defense · Casual

Oxygen Not Included
Shared: Survival · Resource Management · 2D

Kingdom Rush - Tower Defense
Shared: Strategy · Tower Defense · Casual

Factorio
Shared: Strategy · Resource Management · Survival

Cookie Clicker
Shared: Casual · Indie · Management

Kingdom Rush Frontiers - Tower Defense
Shared: Strategy · Tower Defense · 2D

911 Operator
Shared: Strategy · Indie · Casual

Mini Motorways
Shared: Strategy · Casual · Indie

Kingdom Rush Origins - Tower Defense
Shared: Strategy · Tower Defense · Casual

Plague Inc: Evolved
Shared: Strategy · Indie · Casual

RimWorld
Shared: Strategy · Survival · Management

Rock 'N' Roll Defense
Shared: Strategy · Casual · Tower Defense

Bloons TD 5
Shared: Strategy · Tower Defense · Casual

Mini Metro
Shared: Strategy · Indie · Casual

Shelldiver
Shared: Casual · Management · Resource Management

This War of Mine
Shared: Strategy · Survival · Singleplayer

Reus
Shared: Strategy · Indie · Casual

Ninja Kiwi Archive
Shared: Casual · Strategy · Tower Defense

Banished
Shared: Strategy · Indie · Survival

Potion Craft: Alchemist Simulator
Shared: Indie · Singleplayer · Casual

Town of Salem
Shared: Strategy · Indie · Casual

Kingdom Rush 5: Alliance TD
Shared: Strategy · Tower Defense · 2D