Games like Desktop Ant Farm Simulator
Games like Desktop Ant Farm Simulator include WorldBox - God Simulator, Stardew Valley, RimWorld, Prison Architect, and People Playground. We matched them by the tags players give Desktop Ant Farm Simulator on Steam (Simulation, Colony Sim, Sandbox, Idler, and 2D): closest matches first, and among equally close ones the better-known games.

WorldBox - God Simulator
Shared: Simulation · Sandbox · Colony Sim

Stardew Valley
Shared: Pixel Graphics · Simulation · Sandbox

RimWorld
Shared: Colony Sim · Sandbox · Simulation

Prison Architect
Shared: Simulation · Sandbox · Colony Sim

People Playground
Shared: Sandbox · Simulation · 2D

Oxygen Not Included
Shared: Colony Sim · Simulation · Sandbox

Banished
Shared: Colony Sim · Simulation · Sandbox

Potion Craft: Alchemist Simulator
Shared: Simulation · Relaxing · Singleplayer

鬼谷八荒 Tale of Immortal
Shared: Simulation · Sandbox · Singleplayer

Graveyard Keeper
Shared: Simulation · Pixel Graphics · Sandbox

Terraria
Shared: Sandbox · 2D · Pixel Graphics

Rusty's Retirement
Shared: Idler · Simulation · Relaxing

Maltese's Fluffy Onsen
Shared: Simulation · Pixel Graphics · Idler

Sand:box
Shared: Simulation · Sandbox · 2D

Planet Zoo
Shared: Simulation · Sandbox · Nature

Planet Coaster
Shared: Simulation · Sandbox · Relaxing

DAVE THE DIVER
Shared: Pixel Graphics · Relaxing · Simulation

Fabledom
Shared: Colony Sim · Sandbox · Simulation

Clanfolk
Shared: Simulation · Pixel Graphics · Sandbox

House Flipper
Shared: Simulation · Sandbox · Singleplayer

Cast n Chill
Shared: Pixel Graphics · Idler · Relaxing

Mountain
Shared: Simulation · Relaxing · Singleplayer

All Hail the Orb
Shared: Simulation · Colony Sim · Idler

Tiny Pasture
Shared: Idler · Pixel Graphics · Simulation