Games like Defense Protocol
Games like Defense Protocol include Bloons TD 6, Rogue Tower, Plants vs. Zombies GOTY Edition, Vampire Survivors, and Outpost: Infinity Siege. We matched them by the tags players give Defense Protocol on Steam (Casual, Tower Defense, Action-Adventure, Roguelite, and 3D): closest matches first, and among equally close ones the better-known games.

Bloons TD 6
Shared: Tower Defense · Casual · 3D

Rogue Tower
Shared: Tower Defense · Casual · 3D

Plants vs. Zombies GOTY Edition
Shared: Tower Defense · Casual · Singleplayer

Vampire Survivors
Shared: Roguelite · Casual · Indie

Outpost: Infinity Siege
Shared: Tower Defense · 3D · Resource Management

Emberward
Shared: Tower Defense · Roguelite · 3D

Kingdom Rush - Tower Defense
Shared: Tower Defense · Casual · Singleplayer

Kingdom Rush Origins - Tower Defense
Shared: Tower Defense · Casual · Singleplayer

Megabonk
Shared: Roguelite · Indie · Casual

WEBFISHING
Shared: Casual · Indie · 3D

Wall World
Shared: Roguelite · Tower Defense · Action-Adventure

Bills Must Be Paid
Shared: Roguelite · Casual · Indie

Dome Keeper
Shared: Tower Defense · Sci-fi · Singleplayer

Donut County
Shared: Casual · Indie · 3D

Creeper World 3: Arc Eternal
Shared: Tower Defense · Indie · Sci-fi

Apocalypse Party
Shared: Casual · Roguelite · Singleplayer

SpaceEngine
Shared: Casual · Sci-fi · 3D

ForgeTax
Shared: Casual · Roguelite · 3D

Yokai Art: Night Parade of One Hundred Demons
Shared: Tower Defense · Roguelite · Casual

SENTRY
Shared: Tower Defense · Sci-fi · Stylized

Legion TD 2 - Multiplayer Tower Defense
Shared: Tower Defense · Casual · Resource Management

City Defense Z
Shared: Casual · Tower Defense · Roguelite

Star Birds
Shared: Casual · Stylized · Resource Management

Florence
Shared: Casual · Indie · Singleplayer