Games like Defense Grid: The Awakening
Games like Defense Grid: The Awakening include X-Morph: Defense, Infested Planet, Plants vs. Zombies GOTY Edition, Creeper World 3: Arc Eternal, and Sanctum 2. We matched them by the tags players give Defense Grid: The Awakening on Steam (Tower Defense, Strategy, Sci-fi, Singleplayer, and Indie): closest matches first, and among equally close ones the better-known games.

X-Morph: Defense
Shared: Tower Defense · Strategy · Sci-fi

Infested Planet
Shared: Tower Defense · Strategy · Indie

Plants vs. Zombies GOTY Edition
Shared: Tower Defense · Strategy · Singleplayer

Creeper World 3: Arc Eternal
Shared: Tower Defense · Strategy · Indie

Sanctum 2
Shared: Tower Defense · Strategy · Sci-fi

Anomaly Warzone Earth
Shared: Strategy · Tower Defense · Indie

Bloons TD 6
Shared: Tower Defense · Strategy · Singleplayer

XCOM: Enemy Unknown
Shared: Strategy · Sci-fi · Singleplayer

Taur
Shared: Tower Defense · Strategy · Sci-fi

FTL: Faster Than Light
Shared: Strategy · Sci-fi · Indie

Kingdom Rush - Tower Defense
Shared: Tower Defense · Strategy · Singleplayer

Starship Troopers: Terran Command
Shared: Strategy · Singleplayer · Sci-fi

Space Run
Shared: Tower Defense · Strategy · Sci-fi

XCOM®: Chimera Squad
Shared: Strategy · Singleplayer · Sci-fi

Iron Marines
Shared: Strategy · Sci-fi · Singleplayer

Aliens: Dark Descent
Shared: Strategy · Sci-fi · Singleplayer

Rock 'N' Roll Defense
Shared: Tower Defense · Strategy · Indie

Orcs Must Die! 2
Shared: Tower Defense · Strategy · Indie

Sid Meier's Civilization®: Beyond Earth™
Shared: Strategy · Sci-fi · Singleplayer

Dungeon of the ENDLESS™
Shared: Strategy · Tower Defense · Indie

Orcs Must Die!
Shared: Tower Defense · Strategy · Indie

DG2: Defense Grid 2
Shared: Tower Defense · Strategy · Sci-fi

Kingdom Rush Frontiers - Tower Defense
Shared: Tower Defense · Strategy · Singleplayer

Plague Inc: Evolved
Shared: Strategy · Singleplayer · Indie