Games like Defense Builder
Games like Defense Builder include Bloons TD 6, Starship Troopers: Terran Command, Creeper World 4, IDUN - Frontline Survival, and XCOM 2. We matched them by the tags players give Defense Builder on Steam (Strategy, Tower Defense, Sci-fi, War, and Wargame): closest matches first, and among equally close ones the better-known games.

Bloons TD 6
Shared: Strategy · Tower Defense · Singleplayer

Starship Troopers: Terran Command
Shared: Strategy · War · Sci-fi

Creeper World 4
Shared: Tower Defense · Wargame · Strategy

IDUN - Frontline Survival
Shared: Tower Defense · Strategy · 3D

XCOM 2
Shared: Strategy · Sci-fi · War

Broken Arrow
Shared: Strategy · Wargame · War

Creeper World 3: Arc Eternal
Shared: Strategy · Tower Defense · Sci-fi

Totally Accurate Battle Simulator
Shared: Strategy · War · Singleplayer

Plants vs. Zombies GOTY Edition
Shared: Tower Defense · Strategy · Singleplayer

STAR WARS™ Empire at War - Gold Pack
Shared: Strategy · Sci-fi · War

Warpips
Shared: Strategy · Tower Defense · War

Defense Grid: The Awakening
Shared: Strategy · Tower Defense · Sci-fi

Infested Planet
Shared: Strategy · Tower Defense · Sci-fi

Outpost: Infinity Siege
Shared: Tower Defense · 3D · Sci-fi

Aliens: Dark Descent
Shared: Strategy · Sci-fi · Top-Down

FTL: Faster Than Light
Shared: Strategy · Sci-fi · Singleplayer

Warhammer 40,000: Battlesector
Shared: Strategy · 3D · Sci-fi

Minimalist Tower Defense
Shared: Strategy · Tower Defense · Top-Down

Thronefall
Shared: Strategy · Tower Defense · 3D

DG2: Defense Grid 2
Shared: Strategy · Tower Defense · Sci-fi

Bad North: Jotunn Edition
Shared: Tower Defense · Wargame · War

Tempest Rising
Shared: Strategy · 3D · War

Company of Heroes 3
Shared: Strategy · Wargame · Singleplayer

Sanctum 2
Shared: Tower Defense · Strategy · Sci-fi