Games like Defense and Revenge
Games like Defense and Revenge include Othercide, XCOM 2, Darkest Dungeon®, The Last Spell, and Mordheim: City of the Damned. We matched them by the tags players give Defense and Revenge on Steam (Indie, Strategy, Tactical, Turn-Based Combat, and Dark Fantasy): closest matches first, and among equally close ones the better-known games.

Othercide
Shared: Indie · Strategy · Turn-Based Combat

XCOM 2
Shared: Strategy · Tactical · Turn-Based Combat

Darkest Dungeon®
Shared: Turn-Based Combat · Dark Fantasy · Strategy

The Last Spell
Shared: Strategy · Tactical · Turn-Based Combat

Mordheim: City of the Damned
Shared: Tactical · Strategy · Dark Fantasy

Warhammer 40,000: Mechanicus
Shared: Strategy · Turn-Based Combat · Tactical

Plague Inc: Evolved
Shared: Strategy · Indie · Tactical

Loop Hero
Shared: Tactical · Indie · Dark Fantasy

Shadow Tactics: Blades of the Shogun
Shared: Strategy · Tactical · Indie

Iratus: Lord of the Dead
Shared: Strategy · Indie · Turn-Based Combat

Into the Breach
Shared: Strategy · Indie · Tactical

Age of Wonders 4
Shared: Strategy · Turn-Based Combat · Dark Fantasy

Fell Seal: Arbiter's Mark
Shared: Strategy · Indie · Turn-Based Combat

Mutant Year Zero: Road to Eden
Shared: Strategy · Turn-Based Combat · Tactical

Door Kickers
Shared: Strategy · Tactical · Indie

Jagged Alliance 3
Shared: Strategy · Tactical · Turn-Based Combat

FTL: Faster Than Light
Shared: Strategy · Indie · Tactical

Battle Brothers
Shared: Strategy · Tactical · Turn-Based Combat

Slay the Spire 2
Shared: Strategy · Turn-Based Combat · Indie

Quasimorph
Shared: Strategy · Turn-Based Combat · Tactical

HighFleet
Shared: Indie · Strategy · Tactical

Town of Salem
Shared: Strategy · Indie · Tactical

Total War: WARHAMMER III
Shared: Strategy · Dark Fantasy · Tactical

Hard West
Shared: Strategy · Turn-Based Combat · Tactical