Games like Deck of Defense
Games like Deck of Defense include Balatro, Slay the Spire, Slay the Spire 2, Dicey Dungeons, and 9 Kings. We matched them by the tags players give Deck of Defense on Steam (Strategy, Tower Defense, Roguelike Deckbuilder, Roguelite, and Card Game): closest matches first, and among equally close ones the better-known games.

Balatro
Shared: Roguelike Deckbuilder · Card Game · Strategy

Slay the Spire
Shared: Roguelike Deckbuilder · Card Game · Strategy

Slay the Spire 2
Shared: Strategy · Card Game · Roguelike

Dicey Dungeons
Shared: Roguelike Deckbuilder · Roguelite · Deckbuilding

9 Kings
Shared: Strategy · Card Game · Roguelike Deckbuilder

Emberward
Shared: Tower Defense · Strategy · Roguelite

DICEOMANCER
Shared: Strategy · Roguelike Deckbuilder · Card Game

RACCOIN: Coin Pusher Roguelike
Shared: Strategy · Roguelike Deckbuilder · Deckbuilding

Monster Train
Shared: Roguelite · Card Game · Deckbuilding

Monster Train 2
Shared: Roguelike Deckbuilder · Card Game · Strategy

Heretic's Fork
Shared: Tower Defense · Strategy · Roguelike Deckbuilder

Dungeons & Degenerate Gamblers
Shared: Strategy · Roguelike Deckbuilder · Card Game

Cubic Cosmos
Shared: Roguelike Deckbuilder · Strategy · Deckbuilding

Tower Tactics: Liberation
Shared: Tower Defense · Roguelike Deckbuilder · Strategy

Meme Mayhem
Shared: Roguelike Deckbuilder · Card Game · Strategy

Wildfrost
Shared: Roguelike Deckbuilder · Card Game · Roguelite

Luck be a Landlord
Shared: Roguelike Deckbuilder · Strategy · Roguelite

Die in the Dungeon
Shared: Strategy · Roguelike Deckbuilder · Roguelike

Super Fantasy Kingdom
Shared: Strategy · Roguelite · Roguelike

Inscryption
Shared: Card Game · Deckbuilding · Strategy

Yao-Guai Hunter
Shared: Roguelike Deckbuilder · Card Game · Roguelike

Vampire Crawlers: The Turbo Wildcard from Vampire Survivors
Shared: Strategy · Deckbuilding · Roguelike

My Card Is Better Than Your Card!
Shared: Strategy · Card Game · Roguelike

Bloons TD 6
Shared: Strategy · Tower Defense · Cartoony