Games like Chromosome Evil 2
Games like Chromosome Evil 2 include Aliens: Dark Descent, Ultimate Custom Night, Darkwood, This War of Mine, and Five Nights at Freddy's: Sister Location. We matched them by the tags players give Chromosome Evil 2 on Steam (Strategy, RTS, Dark, Survival, and Choices Matter): closest matches first, and among equally close ones the better-known games.

Aliens: Dark Descent
Shared: Strategy · RTS · Dark

Ultimate Custom Night
Shared: Strategy · Horror · Survival

Darkwood
Shared: Dark · Horror · Survival Horror

This War of Mine
Shared: Survival · Strategy · Choices Matter

Five Nights at Freddy's: Sister Location
Shared: Dark · Horror · Strategy

Resident Evil 4
Shared: Horror · Survival · Survival Horror

Frostpunk
Shared: Strategy · Survival · Choices Matter

Five Nights at Freddy's 4
Shared: Dark · Horror · Survival Horror

Subnautica
Shared: Survival · Horror · Singleplayer

Five Nights at Freddy's 2
Shared: Horror · Dark · Survival Horror

Poppy Playtime
Shared: Horror · Dark · Singleplayer

The Forest
Shared: Survival · Horror · Survival Horror

Alien: Isolation
Shared: Horror · Aliens · Survival Horror

Crusader Kings III
Shared: Strategy · RTS · Choices Matter

Outlast
Shared: Horror · Survival · Survival Horror

Beholder
Shared: Strategy · Choices Matter · Dark

Buckshot Roulette
Shared: Dark · Strategy · Horror

Five Nights at Freddy's 3
Shared: Horror · Strategy · Survival Horror

Sons Of The Forest
Shared: Survival · Survival Horror · Horror

Five Nights at Freddy's
Shared: Horror · Survival Horror · Dark

Outlast 2
Shared: Horror · Dark · Survival Horror

Starship Troopers: Terran Command
Shared: Strategy · RTS · Singleplayer

They Are Billions
Shared: Strategy · RTS · Survival

Dawn of Man
Shared: Strategy · Survival · RTS