Games like Chicken Defense
Games like Chicken Defense include Stardew Valley, Oxygen Not Included, Factorio, Rusty's Retirement, and Fields of Mistria. We matched them by the tags players give Chicken Defense on Steam (Tower Defense, Farming Sim, Strategy, 2D, and Cute): closest matches first, and among equally close ones the better-known games.

Stardew Valley
Shared: Farming Sim · Pixel Graphics · Relaxing

Oxygen Not Included
Shared: Base Building · 2D · Strategy

Factorio
Shared: Strategy · Base Building · Crafting

Rusty's Retirement
Shared: Farming Sim · Relaxing · Management

Fields of Mistria
Shared: Farming Sim · Pixel Graphics · Cute

Forager
Shared: Farming Sim · Pixel Graphics · 2D

RimWorld
Shared: Strategy · Base Building · Management

Sheltered
Shared: Strategy · Base Building · Pixel Graphics

Plants vs. Zombies GOTY Edition
Shared: Tower Defense · Strategy · 2D

Prison Architect
Shared: Strategy · Base Building · 2D

Rise to Ruins
Shared: Tower Defense · Strategy · Base Building

DAVE THE DIVER
Shared: Pixel Graphics · Relaxing · Management

Clanfolk
Shared: Farming Sim · Pixel Graphics · Relaxing

Potion Craft: Alchemist Simulator
Shared: Relaxing · 2D · Crafting

Until We Die
Shared: Strategy · Tower Defense · Base Building

Coral Island
Shared: Farming Sim · Relaxing · Agriculture

Mindustry
Shared: Tower Defense · Strategy · Base Building

The Escapists
Shared: Strategy · 2D · Pixel Graphics

They Are Billions
Shared: Strategy · Tower Defense · Base Building

Tiny Pasture
Shared: Farming Sim · Cute · Pixel Graphics

Grim Nights
Shared: Tower Defense · Strategy · 2D

Bloons TD 6
Shared: Tower Defense · Strategy · 2D

Kingdom Two Crowns
Shared: Tower Defense · Strategy · Base Building

Your Big, Cute Monster Farm
Shared: Strategy · Farming Sim · 2D