Games like Chain Detonation
Games like Chain Detonation include Vampire Survivors, Skul: The Hero Slayer, Kingdom Rush - Tower Defense, Rogue Legacy, and Hades. We matched them by the tags players give Chain Detonation on Steam (Action, Fantasy, Action Roguelike, 2D, and Singleplayer): closest matches first, and among equally close ones the better-known games.

Vampire Survivors
Shared: Action Roguelike · 2D · Singleplayer

Skul: The Hero Slayer
Shared: Action · Action Roguelike · Indie

Kingdom Rush - Tower Defense
Shared: 2D · Singleplayer · Fantasy

Rogue Legacy
Shared: Action · Action Roguelike · Singleplayer

Hades
Shared: Action Roguelike · Action · Indie

Kingdom Rush Frontiers - Tower Defense
Shared: 2D · Fantasy · Singleplayer

Kingdom Rush 5: Alliance TD
Shared: 2D · Strategy · Singleplayer

Idle Champions of the Forgotten Realms
Shared: Fantasy · Strategy · Singleplayer

A Dance of Fire and Ice
Shared: Singleplayer · 2D · Fantasy

BlazBlue Entropy Effect
Shared: Action · Action Roguelike · 2D

Cult of the Lamb
Shared: Action Roguelike · Singleplayer · 2D

The Binding of Isaac: Rebirth
Shared: Action Roguelike · Indie · Singleplayer

GemCraft - Chasing Shadows
Shared: Action · Singleplayer · Fantasy

Orcs Must Die!
Shared: Action · Fantasy · Strategy

Kingdom Rush Origins - Tower Defense
Shared: 2D · Singleplayer · Strategy

Megabonk
Shared: Action Roguelike · Action · Indie

Dust: An Elysian Tail
Shared: Action · 2D · Fantasy

Total War: WARHAMMER II
Shared: Fantasy · Strategy · Action

ShellShock Live
Shared: Action · 2D · Strategy

Timberman
Shared: Action · 2D · Casual

UnderMine
Shared: Action Roguelike · Action · Indie

Windowkill
Shared: Action · Action Roguelike · 2D

Octogeddon
Shared: Action · Action Roguelike · Indie

The Binding of Isaac
Shared: Action Roguelike · Action · Indie