Games like Blob Life
Games like Blob Life include Stardew Valley, Graveyard Keeper, Prison Architect, People Playground, and Oxygen Not Included. We matched them by the tags players give Blob Life on Steam (Side Scroller, 2D, Cute, Simulation, and Pixel Graphics): closest matches first, and among equally close ones the better-known games.

Stardew Valley
Shared: Pixel Graphics · Simulation · Sandbox

Graveyard Keeper
Shared: Pixel Graphics · Simulation · Sandbox

Prison Architect
Shared: Simulation · Sandbox · 2D

People Playground
Shared: 2D · Sandbox · Simulation

Oxygen Not Included
Shared: 2D · Building · Simulation

WorldBox - God Simulator
Shared: Simulation · Pixel Graphics · God Game

Terraria
Shared: 2D · Sandbox · Pixel Graphics

鬼谷八荒 Tale of Immortal
Shared: Simulation · Management · Sandbox

SPORE™
Shared: God Game · Simulation · Sandbox

Planet Zoo
Shared: Simulation · Management · Sandbox

Project Highrise
Shared: Simulation · 2D · Management

Planet Coaster
Shared: Simulation · Building · Sandbox

Cities: Skylines
Shared: Simulation · Building · Sandbox

Game Dev Tycoon
Shared: Simulation · 2D · Management

DAVE THE DIVER
Shared: Pixel Graphics · Management · Simulation

Slime Rancher
Shared: Cute · Simulation · Sandbox

Potion Craft: Alchemist Simulator
Shared: Simulation · 2D · Management

RimWorld
Shared: Sandbox · Simulation · Base Building

Fields of Mistria
Shared: Pixel Graphics · Simulation · Cute

Moonstone Island
Shared: 2D · Cute · Pixel Graphics

Two Point Hospital
Shared: Simulation · Management · Building

Sand:box
Shared: 2D · Simulation · Pixel Graphics

Let's Build a Zoo
Shared: Simulation · Pixel Graphics · Cute

TheoTown
Shared: Simulation · Pixel Graphics · Sandbox