Games like Blightened: Relic Keeper
Games like Blightened: Relic Keeper include Blue Prince, Void War, Strange Horticulture, Papers, Please, and Cyber Manhunt 2: New World - The Hacking Simulator. We matched them by the tags players give Blightened: Relic Keeper on Steam (Investigation, Resource Management, Roguelite, Puzzle, and Simulation): closest matches first, and among equally close ones the better-known games.

Blue Prince
Shared: Investigation · Puzzle · Roguelite

Void War
Shared: Roguelite · Resource Management · Choices Matter

Strange Horticulture
Shared: Puzzle · Investigation · Simulation

Papers, Please
Shared: Simulation · Puzzle · Indie

Cyber Manhunt 2: New World - The Hacking Simulator
Shared: Puzzle · Investigation · Mystery

This War of Mine
Shared: Simulation · Resource Management · Choices Matter

Death and Taxes
Shared: Simulation · Choices Matter · Puzzle

Orwell: Keeping an Eye On You
Shared: Investigation · Simulation · Choices Matter

Loop Hero
Shared: Roguelite · Resource Management · Choices Matter

The Operator
Shared: Investigation · Puzzle · Simulation

The Test
Shared: Simulation · Multiple Endings · Choices Matter

The Test: Hypothesis Rising
Shared: Simulation · Choices Matter · Investigation

Beholder Conductor
Shared: Choices Matter · Simulation · Investigation

Darkest Dungeon®
Shared: Dark Fantasy · Difficult · Perma Death

Cyber Manhunt
Shared: Simulation · Puzzle · Mystery

Beholder
Shared: Choices Matter · Simulation · Strategy

Return of the Obra Dinn
Shared: Puzzle · Mystery · Atmospheric

A Perfect Day
Shared: Puzzle · Investigation · Choices Matter

Strange Antiquities
Shared: Puzzle · Investigation · Simulation

The Pale Beyond
Shared: Resource Management · Simulation · Choices Matter

Frostpunk
Shared: Resource Management · Strategy · Simulation

Mini Motorways
Shared: Simulation · Puzzle · Strategy

The Case of the Golden Idol
Shared: Investigation · Puzzle · Mystery

lily's world XD
Shared: Investigation · Puzzle · Simulation