Games like BioSphere: Genesis
Games like BioSphere: Genesis include To The Core, Potion Craft: Alchemist Simulator, Cookie Clicker, Stardew Valley, and My Time at Portia. We matched them by the tags players give BioSphere: Genesis on Steam (Casual, Life Sim, Incremental, God Game, and 2D): closest matches first, and among equally close ones the better-known games.
To The Core
Shared: Casual · Incremental · 2D
Potion Craft: Alchemist Simulator
Shared: Crafting · 2D · Casual
Cookie Clicker
Shared: Incremental · Casual · Indie
Stardew Valley
Shared: Life Sim · Crafting · Casual
My Time at Portia
Shared: Life Sim · Casual · Crafting
Russian Life Simulator
Shared: Incremental · 2D · Casual
Cell to Singularity - Evolution Never Ends
Shared: Incremental · Casual · God Game
Keep on Mining!
Shared: Casual · Incremental · Indie
Melvor Idle
Shared: Casual · 2D · Indie
Timberman
Shared: Casual · 2D · Indie
Forage Wizard
Shared: Casual · Incremental · Crafting
A Game About Feeding A Black Hole
Shared: Casual · Incremental · 2D
Mountain
Shared: Casual · God Game · Indie
SPACEPLAN
Shared: Casual · Incremental · Indie
Reus
Shared: God Game · Casual · Indie
Chinese Parents
Shared: Life Sim · Casual · Indie
Doodle God
Shared: Casual · God Game · Indie
The Adventure of NAYU
Shared: Casual · Incremental · 2D
Nodebuster
Shared: Casual · Incremental · 2D
Paralives
Shared: Life Sim · Casual · Indie
Shelldiver
Shared: Casual · Incremental · 2D
Orb of Creation
Shared: Casual · Incremental · Indie
Zup! S
Shared: Casual · 2D · Indie
Click Mage
Shared: Incremental · Casual · Crafting