Games like Biodome Bastion
Games like Biodome Bastion include Creeper World 4, Offworld Trading Company, Planet Coaster 2, Jurassic World Evolution, and Cliff Empire. We matched them by the tags players give Biodome Bastion on Steam (Simulation, Strategy, Tower Defense, Economy, and Sci-fi): closest matches first, and among equally close ones the better-known games.

Creeper World 4
Shared: Tower Defense · Strategy · Real Time Tactics

Offworld Trading Company
Shared: Strategy · Simulation · 3D

Planet Coaster 2
Shared: Simulation · Strategy · 3D

Jurassic World Evolution
Shared: Simulation · Strategy · Economy

Cliff Empire
Shared: Strategy · Simulation · Sci-fi

Mini Motorways
Shared: Simulation · Strategy · Puzzle

Planet Coaster
Shared: Simulation · Strategy · Economy

Artisan TD
Shared: Strategy · Tower Defense · Puzzle

Cities: Skylines
Shared: Simulation · Strategy · Economy

Totally Accurate Battle Simulator
Shared: Simulation · Strategy · 3D

Prehistoric Kingdom
Shared: Simulation · Strategy · Economy

Ultimate Epic Battle Simulator 2
Shared: Simulation · Strategy · Wargame

Creeper World 3: Arc Eternal
Shared: Strategy · Tower Defense · Simulation

Europa Universalis IV
Shared: Strategy · Simulation · Economy

Europa Universalis V
Shared: Strategy · Simulation · Economy

Jurassic World Evolution 2
Shared: Simulation · Strategy · Economy

Cities: Skylines II
Shared: Simulation · Strategy · Economy

Thronefall
Shared: Strategy · Tower Defense · 3D

Anno 2070™
Shared: Strategy · Simulation · Economy

shapez 2 - Factory
Shared: Strategy · Simulation · Puzzle

Prison Architect
Shared: Simulation · Strategy · Economy

Anno 2205™
Shared: Strategy · Simulation · Sci-fi

Game Dev Tycoon
Shared: Simulation · Strategy · Economy

Bloons TD 6
Shared: Strategy · Tower Defense · 3D