Games like Astral Towers
Games like Astral Towers include Slay the Spire, Slay the Spire 2, Inscryption, Balatro, and Talisman: Digital Classic Edition. We matched them by the tags players give Astral Towers on Steam (Strategy, Indie, Card Game, Puzzle, and Fantasy): closest matches first, and among equally close ones the better-known games.

Slay the Spire
Shared: Card Game · Strategy · Card Battler

Slay the Spire 2
Shared: Card Game · Strategy · Indie

Inscryption
Shared: Card Game · Card Battler · Puzzle

Balatro
Shared: Card Game · Strategy · Indie

Talisman: Digital Classic Edition
Shared: Strategy · Board Game · Indie

Armello
Shared: Card Game · Strategy · Board Game

GWENT: Rogue Mage (Single-Player Expansion)
Shared: Strategy · Card Game · Puzzle

Magic: The Gathering Arena
Shared: Strategy · Card Game · Fantasy

Gordian Quest
Shared: Card Game · Strategy · Card Battler

Library Of Ruina
Shared: Card Game · Strategy · Indie

Stacklands
Shared: Card Game · Strategy · Card Battler

9 Kings
Shared: Strategy · Card Game · Card Battler

GWENT: The Witcher Card Game
Shared: Strategy · Card Game · Fantasy

Idle Champions of the Forgotten Realms
Shared: Strategy · Fantasy · Indie

Gremlins, Inc.
Shared: Strategy · Card Game · Board Game

The Bazaar
Shared: Strategy · Card Game · Card Battler

100% Orange Juice
Shared: Strategy · Board Game · Card Game

None Shall Intrude
Shared: Strategy · Card Game · Card Battler

Gorogoa
Shared: Indie · Puzzle · Hand-drawn

Kingdom Rush 5: Alliance TD
Shared: Strategy · 2D · Fantasy

Roguebook
Shared: Indie · Card Game · Strategy

Wingspan
Shared: Card Game · Strategy · Board Game

Faeria
Shared: Strategy · Card Game · Indie

Kingdom Rush Frontiers - Tower Defense
Shared: Strategy · Fantasy · 2D