Games like Astral Flux
Games like Astral Flux include Caveblazers, No Man's Sky, Rain World, Skul: The Hero Slayer, and Dead Cells. We matched them by the tags players give Astral Flux on Steam (Roguelite, Procedural Generation, Space, Pixel Graphics, and Aliens): closest matches first, and among equally close ones the better-known games.

Caveblazers
Shared: Roguelite · Pixel Graphics · Procedural Generation

No Man's Sky
Shared: Space · Procedural Generation · Exploration

Rain World
Shared: Pixel Graphics · Exploration · Survival

Skul: The Hero Slayer
Shared: Pixel Graphics · Roguelite · Action Roguelike

Dead Cells
Shared: Roguelite · Pixel Graphics · Action Roguelike

FTL: Faster Than Light
Shared: Space · Perma Death · Procedural Generation

Vampire Survivors
Shared: Roguelite · Pixel Graphics · Action Roguelike

Wall World
Shared: Roguelite · Pixel Graphics · Procedural Generation

Noita
Shared: Pixel Graphics · Difficult · Perma Death

The Binding of Isaac: Rebirth
Shared: Pixel Graphics · Action Roguelike · Difficult

Terraria
Shared: Pixel Graphics · Survival · Exploration

30XX
Shared: Roguelite · 2D Platformer · Perma Death

Risk of Rain (2013)
Shared: Pixel Graphics · Action Roguelike · Perma Death

UnderMine
Shared: Roguelite · Pixel Graphics · Action Roguelike

Starbound
Shared: Space · Pixel Graphics · Survival

Celeste
Shared: Pixel Graphics · Difficult · 2D Platformer

The Binding of Isaac
Shared: Procedural Generation · Action Roguelike · Difficult

ScourgeBringer
Shared: Roguelite · Pixel Graphics · Action Roguelike

Dungreed
Shared: Roguelite · Pixel Graphics · Action Roguelike

Void War
Shared: Roguelite · Space · Perma Death

Megabonk
Shared: Roguelite · Action Roguelike · Pixel Graphics

SANABI
Shared: Pixel Graphics · 2D Platformer · Action

Everything is Crab: The Animal Evolution Roguelite
Shared: Roguelite · Pixel Graphics · Action Roguelike

Spelunky 2
Shared: Perma Death · Procedural Generation · 2D Platformer