Games like Astral Ascent
Games like Astral Ascent include Hades, The Binding of Isaac: Rebirth, Hades II, Dead Cells, and Skul: The Hero Slayer. We matched them by the tags players give Astral Ascent on Steam (Action Roguelike, Roguelite, Hack and Slash, Indie, and Atmospheric): closest matches first, and among equally close ones the better-known games.

Hades
Shared: Action Roguelike · Roguelite · Hack and Slash

The Binding of Isaac: Rebirth
Shared: Action Roguelike · Indie · Replay Value

Hades II
Shared: Roguelite · Hack and Slash · Action Roguelike

Dead Cells
Shared: Action Roguelike · Roguelite · Hack and Slash

Skul: The Hero Slayer
Shared: Action Roguelike · Indie · Roguelite

The Binding of Isaac
Shared: Action Roguelike · Indie · Replay Value

Ravenswatch
Shared: Action Roguelike · Roguelite · Indie

Wizard of Legend
Shared: Action Roguelike · Roguelite · Roguelike

SWORN
Shared: Roguelite · Action Roguelike · Indie

Risk of Rain (2013)
Shared: Action Roguelike · Indie · Roguelike

Vampire Survivors
Shared: Action Roguelike · Roguelite · Indie

Megabonk
Shared: Action Roguelike · Roguelite · Indie

Nuclear Throne
Shared: Action Roguelike · Indie · Roguelite

Garden of Witches
Shared: Action Roguelike · Roguelite · Hack and Slash

Enter the Gungeon
Shared: Action Roguelike · Indie · Difficult

Children of Morta
Shared: Hack and Slash · Action Roguelike · Roguelite

One Step From Eden
Shared: Action Roguelike · Roguelite · Difficult

BlazBlue Entropy Effect
Shared: Action Roguelike · Replay Value · Indie

Risk of Rain 2
Shared: Action Roguelike · Roguelite · Roguelike

Hero Siege
Shared: Action Roguelike · Hack and Slash · Indie

Moonlighter
Shared: Hack and Slash · Roguelite · Action Roguelike

Halls of Torment
Shared: Action Roguelike · Roguelite · Hack and Slash

Noita
Shared: Indie · Difficult · Action Roguelike

Cinderia
Shared: Action Roguelike · Roguelite · Hack and Slash