Games like As We Descend
Games like As We Descend include Slay the Spire, Balatro, Slay the Spire 2, Monster Train, and Wildfrost. We matched them by the tags players give As We Descend on Steam (Roguelike Deckbuilder, Card Battler, Card Game, Roguelike, and Deckbuilding): closest matches first, and among equally close ones the better-known games.

Slay the Spire
Shared: Roguelike Deckbuilder · Card Battler · Card Game

Balatro
Shared: Roguelike Deckbuilder · Card Game · Roguelike

Slay the Spire 2
Shared: Card Game · Roguelike · Roguelike Deckbuilder

Monster Train
Shared: Card Battler · Card Game · Deckbuilding

Wildfrost
Shared: Roguelike Deckbuilder · Card Battler · Card Game

9 Kings
Shared: Roguelike · Card Game · Roguelike Deckbuilder

Dicey Dungeons
Shared: Roguelike Deckbuilder · Card Battler · Deckbuilding

Die in the Dungeon
Shared: Roguelike · Roguelike Deckbuilder · Card Game

LONESTAR
Shared: Roguelike · Card Battler · Roguelike Deckbuilder

Dungeons & Degenerate Gamblers
Shared: Roguelike Deckbuilder · Roguelike · Card Game

Monster Train 2
Shared: Roguelike Deckbuilder · Card Game · Roguelike

Inscryption
Shared: Card Battler · Card Game · Deckbuilding

Roguebook
Shared: Card Game · Deckbuilding · Roguelike

Griftlands
Shared: Card Battler · Deckbuilding · Roguelite

Astrea: Six-Sided Oracles
Shared: Roguelike Deckbuilder · Card Battler · Card Game

Super Fantasy Kingdom
Shared: Roguelike · Card Game · Roguelike Deckbuilder

StarVaders
Shared: Roguelike Deckbuilder · Deckbuilding · Turn-Based Tactics

Touhou: Lost Branch of Legend
Shared: Roguelike Deckbuilder · Card Battler · Roguelike

Black Jacket
Shared: Roguelike Deckbuilder · Card Game · Roguelike

Alina of the Arena
Shared: Roguelike Deckbuilder · Roguelike · Card Game

Vampire Crawlers: The Turbo Wildcard from Vampire Survivors
Shared: Card Battler · Roguelike · Deckbuilding

Across the Obelisk
Shared: Roguelike Deckbuilder · Card Game · Roguelike

Vault of the Void
Shared: Roguelike Deckbuilder · Deckbuilding · Card Battler

Yao-Guai Hunter
Shared: Roguelike Deckbuilder · Card Game · Card Battler