Games like Antidote to despair
Games like Antidote to despair include Papers, Please, Strange Horticulture, OneShot, Beholder, and Chants of Sennaar. We matched them by the tags players give Antidote to despair on Steam (Simulation, Medical Sim, Puzzle, Choices Matter, and Stylized): closest matches first, and among equally close ones the better-known games.

Papers, Please
Shared: Simulation · Indie · Puzzle

Strange Horticulture
Shared: Puzzle · Simulation · Dark

OneShot
Shared: Puzzle · Indie · Pixel Graphics

Beholder
Shared: Choices Matter · Simulation · Atmospheric

Chants of Sennaar
Shared: Puzzle · Indie · Atmospheric

Beholder Conductor
Shared: Choices Matter · Simulation · Indie

Strange Antiquities
Shared: Puzzle · Simulation · Dark

There Is No Game: Wrong Dimension
Shared: Puzzle · Indie · Point & Click

Cyber Manhunt 2: New World - The Hacking Simulator
Shared: Puzzle · Atmospheric · Point & Click

Death and Taxes
Shared: Simulation · Choices Matter · Puzzle

Sally Face - Episode One
Shared: Puzzle · Indie · Dark

The Red Strings Club
Shared: Choices Matter · Pixel Graphics · Atmospheric

The Case of the Golden Idol
Shared: Puzzle · Detective · Point & Click

Gorogoa
Shared: Puzzle · Indie · Atmospheric

This War of Mine
Shared: Simulation · Atmospheric · Choices Matter

The Rewinder
Shared: Puzzle · Pixel Graphics · Atmospheric

Beholder 2
Shared: Simulation · Choices Matter · Atmospheric

The Test
Shared: Simulation · Choices Matter · Pixel Graphics

Fran Bow
Shared: Puzzle · Point & Click · Dark

Song of Farca
Shared: Choices Matter · Simulation · Atmospheric

LIMBO
Shared: Puzzle · Indie · Atmospheric

Cyber Manhunt
Shared: Simulation · Puzzle · Indie

Do Not Feed the Monkeys
Shared: Choices Matter · Point & Click · Simulation

This Is the Police
Shared: Choices Matter · Simulation · Management