Games like Ant Farm Simulator
Games like Ant Farm Simulator include Stardew Valley, My Time at Portia, The Sims™ 4, WorldBox - God Simulator, and Potion Craft: Alchemist Simulator. We matched them by the tags players give Ant Farm Simulator on Steam (Simulation, Casual, Sandbox, Farming Sim, and Life Sim): closest matches first, and among equally close ones the better-known games.

Stardew Valley
Shared: Farming Sim · Simulation · Life Sim

My Time at Portia
Shared: Life Sim · Simulation · Farming Sim

The Sims™ 4
Shared: Simulation · Life Sim · Sandbox

WorldBox - God Simulator
Shared: Simulation · Sandbox · Colony Sim

Potion Craft: Alchemist Simulator
Shared: Simulation · Sandbox · Casual

Disney Dreamlight Valley
Shared: Life Sim · Simulation · Sandbox

Paralives
Shared: Simulation · Life Sim · Sandbox

Prison Architect
Shared: Simulation · Sandbox · Colony Sim

The Sims™ 3
Shared: Simulation · Life Sim · Sandbox

Coral Island
Shared: Farming Sim · Simulation · Life Sim

Starsand Island
Shared: Farming Sim · Life Sim · Casual

Clanfolk
Shared: Farming Sim · Simulation · Life Sim

Forage Wizard
Shared: Simulation · Casual · Sandbox

SPORE™
Shared: Sandbox · Simulation · Colony Sim

Two Point Museum
Shared: Simulation · Casual · Sandbox

Nodebuster
Shared: Casual · Simulation · Incremental

I Am Future: Cozy Apocalypse Survival
Shared: Casual · Farming Sim · Simulation

Fields of Mistria
Shared: Farming Sim · Simulation · Life Sim

Russian Life Simulator
Shared: Simulation · Incremental · Casual

Game Dev Tycoon
Shared: Simulation · Casual · 2D

Farm Together
Shared: Simulation · Casual · Farming Sim

A Game About Feeding A Black Hole
Shared: Casual · Incremental · Simulation

Dinkum
Shared: Farming Sim · Simulation · Life Sim

PowerWash Simulator
Shared: Casual · Simulation · Sandbox