Games like Anomaly Defenders
Games like Anomaly Defenders include Infested Planet, GemCraft - Chasing Shadows, X-Morph: Defense, Defense Grid: The Awakening, and Sanctum 2. We matched them by the tags players give Anomaly Defenders on Steam (Strategy, Tower Defense, Action, Indie, and Sci-fi): closest matches first, and among equally close ones the better-known games.

Infested Planet
Shared: Strategy · Tower Defense · Action

GemCraft - Chasing Shadows
Shared: Strategy · Tower Defense · Indie

X-Morph: Defense
Shared: Strategy · Tower Defense · Action

Defense Grid: The Awakening
Shared: Strategy · Tower Defense · Sci-fi

Sanctum 2
Shared: Tower Defense · Strategy · Action

Taur
Shared: Strategy · Tower Defense · Action

Creeper World 3: Arc Eternal
Shared: Strategy · Tower Defense · Indie

Anomaly Warzone Earth
Shared: Strategy · Tower Defense · Indie

FTL: Faster Than Light
Shared: Strategy · Indie · Sci-fi

Orcs Must Die!
Shared: Tower Defense · Strategy · Action

Orcs Must Die! 2
Shared: Tower Defense · Strategy · Action

Kingdom Rush - Tower Defense
Shared: Strategy · Tower Defense · Singleplayer

Bloons TD 6
Shared: Strategy · Tower Defense · Singleplayer

Space Run
Shared: Strategy · Tower Defense · Indie

Revenge of the Titans
Shared: Strategy · Tower Defense · Action

Aliens: Dark Descent
Shared: Strategy · Action · Sci-fi

Plants vs. Zombies GOTY Edition
Shared: Tower Defense · Strategy · Singleplayer

Heat Signature
Shared: Indie · Strategy · Action

Space Pirates and Zombies
Shared: Action · Indie · Strategy

Kingdom Rush 5: Alliance TD
Shared: Strategy · Tower Defense · Singleplayer

Door Kickers
Shared: Strategy · Action · Indie

Sanctum
Shared: Tower Defense · Strategy · Action

Dome Keeper
Shared: Action · Singleplayer · Sci-fi

Anomaly 2
Shared: Strategy · Action · Tower Defense