Games like Alien Slayer
Games like Alien Slayer include Skul: The Hero Slayer, Vampire Survivors, The Binding of Isaac, Hotline Miami, and UnderMine. We matched them by the tags players give Alien Slayer on Steam (Action, Shooter, Choices Matter, Perma Death, and Singleplayer): closest matches first, and among equally close ones the better-known games.

Skul: The Hero Slayer
Shared: Action · Pixel Graphics · 2D

Vampire Survivors
Shared: Pixel Graphics · 2D · Singleplayer

The Binding of Isaac
Shared: Action · Top-Down · Indie

Hotline Miami
Shared: Action · Top-Down · Pixel Graphics

UnderMine
Shared: Action · Pixel Graphics · Singleplayer

The Binding of Isaac: Rebirth
Shared: Pixel Graphics · Singleplayer · Indie

Nuclear Throne
Shared: Action · Pixel Graphics · Action Roguelike

Enter the Gungeon
Shared: Pixel Graphics · Action · Action Roguelike

Risk of Rain (2013)
Shared: Action · Pixel Graphics · Perma Death

Broforce
Shared: Action · Pixel Graphics · 2D

Hotline Miami 2: Wrong Number
Shared: Action · Pixel Graphics · Top-Down

Battlefield™ 2042
Shared: Shooter · Action · Singleplayer

Titanfall® 2
Shared: Shooter · Action · Singleplayer

Rogue Legacy
Shared: Action · Singleplayer · 2D

Noita
Shared: Pixel Graphics · Perma Death · 2D

Undertale
Shared: Choices Matter · Singleplayer · Pixel Graphics

Dead Cells
Shared: 2D · Pixel Graphics · Action

BlazBlue Entropy Effect
Shared: Action · 2D · Pixel Graphics

Dungreed
Shared: Action · Pixel Graphics · 2D

Dome Keeper
Shared: Action · Singleplayer · Pixel Graphics

BALL x PIT
Shared: Action · Top-Down · Pixel Graphics

Vagante
Shared: Action · Choices Matter · Pixel Graphics

Crysis Remastered
Shared: Action · Shooter · Singleplayer

Call of Duty®
Shared: Shooter · Action · Singleplayer