Games like Alien Defense
Games like Alien Defense include The Riftbreaker, Orcs Must Die! 2, Bastion, Defense Grid: The Awakening, and Black Myth: Wukong. We matched them by the tags players give Alien Defense on Steam (RPG, Tower Defense, Wargame, 2.5D, and Aliens): closest matches first, and among equally close ones the better-known games.

The Riftbreaker
Shared: Tower Defense · Base Building · RPG

Orcs Must Die! 2
Shared: Tower Defense · RPG · Action

Bastion
Shared: RPG · Indie · Singleplayer

Defense Grid: The Awakening
Shared: Tower Defense · Aliens · Singleplayer

Black Myth: Wukong
Shared: RPG · Action · Singleplayer

Deathtrap
Shared: RPG · Tower Defense · Action

鬼谷八荒 Tale of Immortal
Shared: RPG · Singleplayer · Action

Wolcen: Lords of Mayhem
Shared: RPG · Singleplayer · Action

Kingdom Two Crowns
Shared: Tower Defense · Base Building · Singleplayer

Night of the Dead
Shared: Tower Defense · Singleplayer · Base Building

Hades
Shared: Indie · Singleplayer · RPG

Taur
Shared: Tower Defense · Base Building · Action

Mount & Blade II: Bannerlord
Shared: RPG · Singleplayer · Action

Bloodstained: Ritual of the Night
Shared: RPG · 2.5D · Action

ANNO: Mutationem
Shared: RPG · 2.5D · Indie

Middle-earth: Shadow of War
Shared: RPG · Singleplayer · Action

Fallout: New Vegas
Shared: RPG · Singleplayer · Action

Kingdom Come: Deliverance II
Shared: RPG · Singleplayer · Action

Warpips
Shared: Tower Defense · Singleplayer · 2.5D

Infested Planet
Shared: Tower Defense · Action · Singleplayer

Wandering Sword
Shared: RPG · 2.5D · Singleplayer

Sang-Froid - Tales of Werewolves
Shared: Tower Defense · RPG · Indie

X-Morph: Defense
Shared: Tower Defense · Indie · Action

Dust: An Elysian Tail
Shared: RPG · Action · Indie