Games like Against the Gradient
Games like Against the Gradient include while True: learn(), Human Resource Machine, Mini Metro, 7 Billion Humans, and Kerbal Space Program. We matched them by the tags players give Against the Gradient on Steam (Education, Puzzle, Science, Touch-Friendly, and Indie): closest matches first, and among equally close ones the better-known games.

while True: learn()
Shared: Education · Puzzle · Science

Human Resource Machine
Shared: Puzzle · Education · Indie

Mini Metro
Shared: Puzzle · Indie · Simulation

7 Billion Humans
Shared: Puzzle · Education · Indie

Kerbal Space Program
Shared: Science · Simulation · Education

Mini Motorways
Shared: Puzzle · Casual · Simulation

Poly Bridge
Shared: Puzzle · Simulation · Indie

LYNE
Shared: Puzzle · Casual · Mouse Only

Universe Sandbox
Shared: Education · Science · Simulation

Zup! Z
Shared: Puzzle · Indie · Casual

Hexcells Infinite
Shared: Puzzle · Casual · Indie

Hexcells
Shared: Puzzle · Indie · Casual

Hook
Shared: Puzzle · Casual · Indie

Zup! F
Shared: Puzzle · Indie · Casual

Papers, Please
Shared: Indie · Puzzle · Simulation

Electrician Simulator
Shared: Education · Simulation · Indie

10,000,000
Shared: Puzzle · Indie · Mouse Only

Zup! S
Shared: Puzzle · Indie · Casual

Car Mechanic Simulator 2014
Shared: Education · Puzzle · Simulation

Poly Bridge 2
Shared: Puzzle · Simulation · Education

Hexcells Plus
Shared: Puzzle · Indie · Casual

There Is No Game: Wrong Dimension
Shared: Puzzle · Indie · Casual

SpaceChem
Shared: Puzzle · Indie · Science

Bridge Constructor Portal
Shared: Puzzle · Simulation · Level Editor

