Games like Ad Astra: Sci-Fi Tower Defense
Games like Ad Astra: Sci-Fi Tower Defense include Taur, Creeper World 3: Arc Eternal, Mindustry, Age of Darkness: Final Stand, and Thronefall. We matched them by the tags players give Ad Astra: Sci-Fi Tower Defense on Steam (Indie, Strategy, Action RTS, Tower Defense, and RTS): closest matches first, and among equally close ones the better-known games.

Taur
Shared: Strategy · Tower Defense · Indie

Creeper World 3: Arc Eternal
Shared: Strategy · Indie · Tower Defense

Mindustry
Shared: Tower Defense · Strategy · Base Building

Age of Darkness: Final Stand
Shared: Action RTS · Tower Defense · Strategy

Thronefall
Shared: Strategy · Tower Defense · Action RTS

Diplomacy is Not an Option
Shared: Resource Management · Base Building · RTS

They Are Billions
Shared: Strategy · Base Building · RTS

Defense Grid: The Awakening
Shared: Strategy · Tower Defense · Indie

Bee Island
Shared: Strategy · Tower Defense · Action RTS

Warhammer 40,000: Dawn of War - Definitive Edition
Shared: Strategy · RTS · Base Building

Infested Planet
Shared: Strategy · Tower Defense · Indie

Cossacks 3
Shared: Strategy · RTS · Action RTS

Warhammer 40,000: Dawn of War III
Shared: Strategy · RTS · Sci-fi

DG2: Defense Grid 2
Shared: Strategy · Tower Defense · Sci-fi

Age of Mythology: Retold
Shared: Strategy · RTS · Base Building

Command & Conquer 3 Tiberium Wars™
Shared: Strategy · RTS · Action RTS

The King is Watching
Shared: Tower Defense · Base Building · RTS

Tempest Rising
Shared: Strategy · RTS · Base Building

Age of Empires II (Retired)
Shared: Strategy · RTS · Base Building

Warhammer 40,000: Dawn of War - Anniversary Edition (Classic)
Shared: Strategy · RTS · Base Building

Warpips
Shared: Strategy · Tower Defense · RTS

Tower Dominion
Shared: Strategy · Tower Defense · Base Building

Starship Troopers: Terran Command
Shared: Strategy · RTS · Sci-fi

Anomaly Warzone Earth
Shared: Indie · Strategy · Tower Defense