Games like 2D Factory
Games like 2D Factory include Terraria, Stardew Valley, Factorio, Satisfactory, and Prison Architect. We matched them by the tags players give 2D Factory on Steam (Simulation, Sandbox, Exploration, 2D, and Pixel Graphics): closest matches first, and among equally close ones the better-known games.

Terraria
Shared: Sandbox · 2D · Pixel Graphics

Stardew Valley
Shared: Pixel Graphics · Simulation · Sandbox

Factorio
Shared: Sandbox · Automation · Crafting

Satisfactory
Shared: Automation · Sandbox · Exploration

Prison Architect
Shared: Simulation · Sandbox · Building

DAVE THE DIVER
Shared: Pixel Graphics · Exploration · Simulation

Core Keeper
Shared: Exploration · Sandbox · Pixel Graphics

Starbound
Shared: Sandbox · Pixel Graphics · Exploration

Graveyard Keeper
Shared: Simulation · Pixel Graphics · Sandbox

Sandustry
Shared: Sandbox · Automation · Exploration

shapez
Shared: Sandbox · Automation · Crafting

Growtopia
Shared: Simulation · Sandbox · Exploration

People Playground
Shared: Sandbox · 2D · Simulation

Planet Coaster
Shared: Simulation · Sandbox · Building

Forager
Shared: Pixel Graphics · Sandbox · 2D

House Flipper
Shared: Simulation · Sandbox · Building

Oxygen Not Included
Shared: Sandbox · 2D · Simulation

The Escapists
Shared: Pixel Graphics · Simulation · 2D

Littlewood
Shared: Simulation · Pixel Graphics · Sandbox

Dyson Sphere Program
Shared: Simulation · Automation · Building

Keplerth
Shared: Sandbox · Exploration · Building

Graveyard Keeper 2
Shared: Sandbox · Building · Pixel Graphics

Potion Craft: Alchemist Simulator
Shared: Simulation · 2D · Crafting

Disney Dreamlight Valley
Shared: Exploration · Simulation · Sandbox